ASIANET: SCICLONE'S ZADAXIN(R) THYMOSIN ALPHA 1 IS EFFECTIVE AND SAFE...

Press Releases »

SCICLONE'S ZADAXIN(R) THYMOSIN ALPHA 1 IS EFFECTIVE AND SAFE
IN THE TREATMENT OF CHRONIC HEPATITIS B, HEPATOLOGY ARTICLE REPORTS
ZADAXIN RESPONSE RATES INCREASE AFTER THERAPY ENDS

SAN MATEO, Calif., May 29 /PRNewswire-AsiaNet/-- SciClone Pharmaceuticals (Nasdaq: SCLN), today announced that results from the Company's Taiwan phase 3 trial published in Hepatology (May 1998) demonstrate that ZADAXIN(R) thymosin alpha 1 is effective and safe in the treatment of chronic hepatitis B. Importantly, the ZADAXIN complete virologic response rate (the conversion from both hepatitis B virus positive to negative and hepatitis B e antigen positive to negative) in the study continues to increase even when measured one year after the end of treatment.
The publication on the study's primary site data, written by Professor Yun-Fang Liaw, M.D. and his colleagues of the Chang Gung Memorial Hospital, Taiwan, included 98 Asian patients with chronic hepatitis B.  At the start of the study, patients were randomized to receive 1.6 mg of ZADAXIN two times per week for 26 weeks, 52 weeks or no treatment.  Patients were followed for a total of 18 months.
The publication highlights that patients receiving ZADAXIN showed:

* Statistically significant increase in conversion from both hepatitis B

virus positive to negative and hepatitis B e antigen positive to

negative.

At the end of the study, 40.6% of patients receiving 1.6 mg of ZADAXIN

twice per week for 26 weeks tested negative for both hepatitis B virus

and hepatitis B e antigen (an immune response to the hepatitis B virus

that can indicate long lasting remission of the disease) compared to

9.4% of patients in the control group, a statistically significant

result (p=.004).

* Statistically significant histological improvement.

Patients responding to ZADAXIN showed statistically significant

improvement in liver histology (inflammation of the liver) (p<.05),

consistent with the ultimate goals of therapy for hepatitis B -- to

prevent progression to serious liver disease, including liver cancer and

cirrhosis.

* Experienced no significant side effects.

Professor Liaw and his co-workers, commenting on this recent Hepatology article, said:  "Thymosin alpha 1 is safe and effective in the treatment of chronic hepatitis B.  The thymosin alpha 1 response rate is statistically significant in the six month treatment group when compared to control.  It also reduces liver inflammation.  Thymosin alpha 1 therapy offers renewed hope in the fight against chronic hepatitis B."   Hepatitis B is a potentially deadly liver disease and one of the most common causes of death in the world.
According to the World Health Organization, approximately 350 million people, or 5% of the world's population, are chronic carriers of the hepatitis B virus in their blood. These carriers of the hepatitis B virus have a 200-fold increased chance of developing serious liver disease, including liver cancer, the most common cancer in the world, and cirrhosis.  Currently, ZADAXIN and interferon (a drug that produces a sustained response in less than one third of Asian patients treated and causes debilitating side effects) are the only established therapies for hepatitis B in certain Asian markets, including the People's Republic of China.

SciClone markets ZADAXIN in the People's Republic of China, the Philippines and Singapore for the treatment of hepatitis B.  The drug also has been approved in Peru and Kuwait for treatment of hepatitis B and in Argentina and Italy as an influenza vaccine adjuvant.  SciClone's exclusive Japanese partner, Schering-Plough K.K., recently launched a Phase 3 study of ZADAXIN in Japan for hepatitis B.  SciClone has 18 ZADAXIN hepatitis B marketing applications pending in Asia, Latin American and the Middle East.  SciClone intends to file a ZADAXIN hepatitis B marketing application in Taiwan during the second quarter.

SciClone Pharmaceuticals, Inc. is an international biopharmaceutical company that acquires, develops and commercializes specialist-oriented drugs for treating chronic and life-threatening diseases, including hepatitis B, hepatitis C, cystic fibrosis, cancer and immune system disorders.  Press releases and corporate information from SciClone Pharmaceuticals are available on the Internet at www.sciclone.com and by fax at 800-996-7256.

SOURCE  SciClone Pharmaceuticals, Inc.

-0-                             05/29/98

/CONTACT:  Shawn K. Singh, Senior Vice President of SciClone Pharmaceuticals, 650-358-3456/   /Company News On-Call:
http://www.prnewswire.com or fax, 800-758-5804, ext. 775865/   /Web site:
http://www.sciclone.com/   (SCLN)




ข่าวSciClone Pharmaceuticals+PRNewswireวันนี้

Menarini Group and SciClone Pharmaceuticals Announce Exclusive Sub-Licensing Collaboration to Develop and Commercialize ORSERDU(R) (Elacestrant) in China to Address Advanced or Metastatic Breast Cancer

ORSERDU is the first treatment specifically approved for patients with ER+, HER2- advanced or metastatic breast cancer tumors that harbor ESR1 mutations, representing the first innovation in endocrine therapy in nearly 20 years. ESR1 mutations are present in up to 40% of ER+, HER2- advanced or metastatic breast cancers, and are a known driver of resistance to standard endocrine therapy, making these tumors more difficult to treat. This agreement includes undisclosed upfront, milestone payments

ทาทา เทคโนโลยีส์ ขึ้นแท่นผู้ให้บริการ ER&D ชั้นนำของโลกเป็นปีที่ 6 ติดต่อกันในการจัดอันดับประจำปี 2565 ของซินนอฟ โซนส์

ทาทา เทคโนโลยีส์ ขึ้นแท่นผู้เชี่ยวชาญด้านบริการ ER&D ระบบไฟฟ้าอันดับหนึ่งของอินเดีย และอันดับสองของโลก ในฐานะ ESP ในดวงใจของบรรดา OEM ที่ต้องการยกระดับระบบไฟฟ้าของตนไปข้างหน้า ปู...

Zoomlion Brings Nine Leading Product Lines to bauma China 2020

Live-streaming groundbreaking breakthroughs including lightweight technology and voice interaction SHANGHAI, Nov. 20, 2020 /PRNewswire/ Zoomlion Heavy Industry Science & Technology Co., Ltd. (Zoomlion) will exhibit over 50 sets of...

ASIANET: SCHERING-PLOUGH K.K. STARTS PIVOTAL PHASE 3 HEPATITIS B STUDY

SCHERING-PLOUGH K.K. STARTS PIVOTAL PHASE 3 HEPATITIS B STUDY OF SCICLONE'S ZADAXIN(R) THYMOSIN ALPHA 1 IN JAPAN SAN MATEO, Calif., May 12 /PRNewswire/AsiaNet/ SciClone Pharmaceuticals (Nasdaq: SCLN), announced today that Schering...

ASIANET: SCICLONE OBTAINS FIRST EUROPEAN MARKETING APPROVAL AND NEW DRUG

SCICLONE OBTAINS FIRST EUROPEAN MARKETING APPROVAL AND NEW DRUG APPLICATIONFOR ZADAXIN(R) THYMOSIN ALPHA 1- DEAL POSITIONS THE COMPANY FOR A U.S. ANDPAN EUROPEAN PARTNERING ARRANGEMENT - SAN MATEO, Calif., April 21 /PRNewswire...

ASIANET: SCICLONE'S ZADAXIN(R) THYMOSIN ALPHA 1 IN COMBINATION WITH TACE IMPROVED SURVIVAL OF LIVER CANCER PATIENTS

SCICLONE'S ZADAXIN(R) THYMOSIN ALPHA 1 IN COMBINATION WITH TACE IMPROVED SURVIVAL OF LIVER CANCER PATIENTS, STUDY FINDS SAN MATEO, Calif., March 27 /PRNewswire-Asianet/ SciClone...

ASIANET: ญี่ปุ่นไฟเขียว Schering-Plough ผลิตยาต้านไวรัสตับอักเสบบีขั้น 3

บริษัท SciClone Pharmaceuticals, Inc. (SCLN)ได้ประกาศในวันนี้ว่า บริษัท Schering-Plough K.K. (SPKK) ซึ่งเป็นบริษัทในญี่ปุ่นในเครือของบริษัท Schering-Plough Corporation ได้รับการอนุมัติจากกระทรวงสาธารณสุขและสวัสดิการของญี่ปุ่น...

ASIANET: SCICLONE AND SCHERING-PLOUGH K.K. RECEIVE JAPANESE APPROVAL TO START THE PIVOTAL PHASE 3 HEPATITIS B STUDY FOR ZADAXIN (R) THYMOSIN ALPHA 1 IN JAPAN

SCICLONE AND SCHERING-PLOUGH K.K. RECEIVE JAPANESE APPROVAL TO START THE PIVOTAL PHASE 3 HEPATITIS B STUDY FOR ZADAXIN(R) THYMOSIN ALPHA 1 IN...